New 1, 4-dihydropyridine derivatives combining calcium antagonism and. alpha.-adrenolytic properties
G Marciniak, A Delgado, G Leclerc, J Velly…
Index: Marciniak; Delgado; Leclerc; Velly; Decker; Schwartz Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1402 - 1407
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Citation Number: 88
Abstract
A series of twelve 1, 4-dihydropyridine derivatives incorporating an a-adrenergic moiety in one of the ester chains was synthesized. The compounds were evaluated for their calcium antagonist activities by the inhibition of [3H] nitrendipine binding and, in vitro, on pig coronary artery. Their al-and a,-adrenolytic effects were assessed from their inhibition of [3H] prazosin and [3H] yohimbine binding and, in vitro, on rat aorta and guinea pig vas ...
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[Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676]
[Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676]