Synthesis of simplified herboxidiene aromatic hybrids

…, L Hagmann, R Schaffner, H Furlenmeier

Index: Edmunds; Arnold; Hagmann; Schaffner; Furlenmeier Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 12 p. 1365 - 1368

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Citation Number: 17

Abstract

Herboxidiene (1) is a novel polyketide natural product isolated from Streptomyces sp. A 7847 by workers at Monsanto. This compound controls (>90%) several important biannual weeds at relatively low application rates (<250 g hectare −1 ) without damaging wheat. 1 The relative and absolute configuration of 1 was deduced by a combination of X-ray analysis, asymmetric synthesis, and degradation studies, 2 and the first synthesis of the natural product has ...