Tetrahedron letters

Synthesis of γ-halogenated ketones via the Ce (IV)-mediated oxidative coupling of cyclobutanols and inorganic halides

BM Casey, CA Eakin, RA Flowers

Index: Casey, Brian M.; Eakin, Cynthia A.; Flowers II, Robert A. Tetrahedron Letters, 2009 , vol. 50, # 12 p. 1264 - 1266

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Citation Number: 23

Abstract

A straightforward method for the synthesis of γ-halo-substituted ketones formed via the CAN- initiated oxidative addition of halides to 1-substituted cyclobutanols has been developed. This method has short reaction times, and provides access to a range of bromo and iodo γ- substituted ketones in good to excellent yields.

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