Tetrahedron

Synthesis and evaluation of halogenated nitrophenoxazinones as nitroreductase substrates for the detection of pathogenic bacteria

AF Bedernjak, PW Groundwater, M Gray, AL James…

Index: Bedernjak, Alexandre F.; Groundwater, Paul W.; Gray, Mark; James, Arthur L.; Orenga, Sylvain; Perry, John D.; Anderson, Rosaleen J. Tetrahedron, 2013 , vol. 69, # 39 p. 8456 - 8462

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Abstract

Abstract The synthesis and microbiological evaluation of 7-, 8-and 9-nitro-1, 2, 4- trihalogenophenoxazin-3-one substrates with potential in the detection of nitroreductase- expressing pathogenic microorganisms are described. The 7-and 9- nitrotrihalogenophenoxazinone substrates were reduced by most Gram-negative microorganisms and were inhibitory to the growth of certain Gram-positive bacteria; ...