Solid phase synthesis of benzylamine-derived sulfonamide library

SW Kim, CY Hong, K Lee, EJ Lee, JS Koh

Index: Kim, Sang Woong; Hong, Chang Yong; Lee, Koo; Lee, Eun Ju; Koh, Jong Sung Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 735 - 738

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Citation Number: 36

Abstract

Using solid phase synthesis, a library has been constructed of benzylamine-derived sulfonamides which have strong inhibitory activity against the blood coagulant thrombin. The library compounds were obtained in good yield and high purity; four of these thrombin inhibitors showed nanomolar potency (Ki 600-10 nM).