Journal of the American Chemical Society

Synthesis of Certain β-Diketones from Acid Chlorides and Ketones by Sodium Amide. Mono versus Diacylation of Sodio Ketones with Acid Chlorides1

BO Linn, CR Hauser

Index: Linn; Hauser Journal of the American Chemical Society, 1956 , vol. 78, p. 6066,6069

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Citation Number: 3

Abstract

The acylation of methyl or methylene ketones with esters by means of bases furnishes probably the best general method for the synthesis of many P-diketone~.~ However, a number of such acylations with the common ethyl or methyl esters have been unsuccessful even when the ester was added to the reactive, intermediate sodio ketone which was prepared by means of sodium amide (equation