Synthetic studies of the pyrroloquinoline nucleus of the makaluvamine alkaloids. Synthesis of the topoisomerase II inhibitor makaluvamine D

JD White, KM Yager, T Yakura

Index: White, James D.; Yager, Kraig M.; Yakura, Takayuki Journal of the American Chemical Society, 1994 , vol. 116, # 5 p. 1831 - 1838

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Citation Number: 80

Abstract

Abstract: A new synthesis of the pyrrolo [4, 3, 2-de] quinoline system characteristic of a class of marine alkaloids which includes the prianosins, discorhabdins, and other antineoplastic agents has been developed. The approach is exemplified in a total synthesis of makaluvamine D, a topoisomerase I1 inhibitor isolated from the sponge Zyzzya cf. marsailis. The route begins with a Fischer indole synthesis employing (2, 3-dimethoxyphenyl) ...