Investigation on the Formation and Hydrolysis of N, N-Dimethylcarbamoyl Chloride (DMCC) in Vilsmeier Reactions Using GC/MS as the Analytical Detection Method

…, K Laniewski, A Westermark, M Sjögren…

Index: Stare, Martina; Laniewski, Krzysztof; Westermark, Andreas; Sjoegren, Magnus; Tian, Wei Organic Process Research and Development, 2009 , vol. 13, # 5 p. 857 - 862

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Citation Number: 8

Abstract

The formation of N, N-dimethylcarbamoyl chloride (DMCC) in Vilsmeier reactions (VRs) and the hydrolysis of DMCC during aqueous workup were investigated. The amount of DMCC formed was dependent on the chlorination reagent. The activity order was found to be: thionyl chloride> oxalyl chloride> phosphorus oxychloride. The concentrations of DMCC found in the tested reactions were normally at a level of 0− 20 ppm. In the presence of a ...

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