Efficient radical domino approach to β-aminoalcohols from arylamines and alcohols triggered by Ti (III)/t-BuOOH

R Spaccini, A Ghilardi, N Pastori, A Clerici, C Punta…

Index: Spaccini, Raffaele; Ghilardi, Alessandra; Pastori, Nadia; Clerici, Angelo; Punta, Carlo; Porta, Ombretta Tetrahedron, 2010 , vol. 66, # 11 p. 2044 - 2052

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Citation Number: 14

Abstract

We report that an aqueous Ti (III)/t-BuOOH system promotes the efficient domino radical reaction of arylamines with alcohol cosolvents leading to β-aminoalcohols in good yields, in less than ten minutes at room temperature. The free-radical mechanism according to which the amine reacts with two molecules of the alcohol is discussed.