Selective metallation of thiophene and thiazole rings with magnesium amide base
M Shilai, Y Kondo, T Sakamoto
Index: Shilai, Manabu; Kondo, Yoshinori; Sakamoto, Takao Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 4 p. 442 - 444
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Citation Number: 46
Abstract
Hydrogen–metal exchange reaction of aromatic and heteroaromatic rings such as directed ortho metallation or direct metallation has been developed as one of the major tools of organic synthesis. 1 Various strong bases such as alkyllithiums or lithium dialkylamides have been used for hydrogen–metal exchange of aromatics. However, organolithium compounds show high reactivity toward electrophilic groups and the use of organolithium ...
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