Organic letters

A novel route to 2, 3-pyrazol-1 (5 H)-ones via palladium-catalyzed carbonylation of 1, 2-diaza-1, 3-butadienes

RK Boeckman, JE Reed, P Ge

Index: Boeckman Jr., Robert K.; Reed, Jessica E.; Ge, Ping Organic Letters, 2001 , vol. 3, # 23 p. 3651 - 3653

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Citation Number: 54

Abstract

A novel Pd (0)-catalyzed carbonylation of both isolable 1, 2-diaza-1, 3-butadienes and those generated in situ by extrusion of SO2 and CO2 from heterocyclic precursors is described. The reaction proceeds at room temperature to 110° C under 1-2 atm of CO to afford 2, 3- pyrazol-1 (5H)-ones in good to excellent yields. The effect of catalyst structure and stability on the carbonylation reaction is evaluated.

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