2, 2′-Pyridoin derivatives protect HL-60 cells against oxidative stress

…, C Nishizawa, T Kakinoki, K Takahashi…

Index: Hatanaka, Masashi; Nishizawa, Chiho; Kakinoki, Tomohiro; Takahashi, Kyoko; Nakamura, Shigeo; Mashino, Tadahiko Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 19 p. 5290 - 5293

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Citation Number: 12

Abstract

Focusing on 2, 2′-pyridoin (1, 1, 2-di (2-pyridyl)-1, 2-ethenediol) and its synthetic derivatives as the lead compound of the potent antioxidative enediol, their protective effect against oxidative stress was evaluated on the HL-60 cell system. 2, 2′-Pyridoins showed no remarkable cytotoxic effect on HL-60 cells. The derivatives 1, 2, 3, 5, and 6 inhibited H2O2-induced cell death and intracellular oxidative stress more significantly than ascorbic ...