The Journal of organic chemistry

Efficient Suzuki-Miyaura coupling of (hetero) aryl chlorides with thiophene-and furanboronic acids in aqueous n-butanol

CA Fleckenstein, H Plenio

Index: Fleckenstein, Christoph A.; Plenio, Herbert Journal of Organic Chemistry, 2008 , vol. 73, # 8 p. 3236 - 3244

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Citation Number: 98

Abstract

An efficient Suzuki cross-coupling protocol enables the reaction of N-hetero and normal aryl chlorides with thiophene-and furanboronic acids. Coupling is effected in aqueous n-butanol as the solvent in near quantitative yield with a catalyst loading of 0.1-1 mol%. For heterocyclic substrates aqueous catalysis is found to be more efficient than Suzuki coupling under anhydrous conditions. The developed Suzuki coupling procedure utilizes ...

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