Synlett

Rapid one-pot synthesis of antiparasitic quinolines based upon the microwave-assisted coupling-isomerization reaction (MACIR)

OG Schramm, T Oeser, M Kaiser, R Brun, TJJ Mueller

Index: Schramm, Oana G.; Oeser, Thomas; Kaiser, Marcel; Brun, Reto; Mueller, Thomas J. J. Synlett, 2008 , # 3 p. 359 - 362

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Citation Number: 16

Abstract

Abstract 2-Substituted quinolines and related derivatives can be rapidly prepared from (hetero) aryl halides and propargyl alcohols in the sense of a one-pot microwave-assisted coupling-isomerization reaction (MACIR). First biological tests against trypanosomes and protozoans have revealed antiparasitic activity in the lower micromolar range.

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