Synthesis and protein kinase C inhibitory activities of balanol analogues with modification of 4-hydroxybenzamido moiety

H Hu, JS Mendoza, CT Lowden, LM Ballas…

Index: Hu, Hong; Mendoza, Jose S.; Lowden, Christopher T.; Ballas, Lawrence M.; Janzen, William P. Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 9 p. 1873 - 1882

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Citation Number: 17

Abstract

A series of racemic balanol analogues with modification of the benzamido moiety of balanol have been synthesized and evaluated for their inhibitory activities against human protein kinase C isozymes (PKC-alpha,-beta I,-beta II,-gamma,-delta,-epsilon, and-eta). The structural modification includes replacement of the 4-hydroxyphenyl group with variously substituted phenyl rings, substitution of the amide linkage with a sulfonamide or an ester, ...