New synthesis of benzo-δ-carbolines, cryptolepines, and their salts: in vitro cytotoxic, antiplasmodial, and antitrypanosomal activities of δ-carbolines, benzo-δ- …

…, F Marsais, A Godard, G Quéguiner

Index: Arzel; Rocca; Grellier; Labaeid; Frappier; Gueritte; Gaspard; Marsais; Godard; Queguiner Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 949 - 960

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Citation Number: 125

Abstract

The paper describes, in its first part, a new synthesis of benzo-δ-carbolines, cryptolepines, and their salts. The strategy is based on the association between halogen-dance and hetero- ring cross-coupling. It is fully convergent and regioselective with interesting overall yields from 27% to 70%. A halogen-dance mechanism in quinoline series is also proposed. The formal synthesis of potential antimalarial compounds and the first total synthesis of 11- ...

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