4-Sulfonamidoanilide tertiary carbinols: A novel series of potassium channel openers

…, D Mayhugh, CJ Ohnmacht, CA Frank, T Grant…

Index: Empfield; Mayhugh; Ohnmacht; Frank; Grant; Li Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 7 p. 775 - 778

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Citation Number: 9

Abstract

Sulfonamides are viable replacements for the phenylsulfonyl and benzoyl moieties initially described for the anilide tertiary carbinol series of KATP potassium channel openers. The SAR of this new series and the synthetic chemistry employed to generate its members are described.