4-Aryl-3-(mercapto) quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle

P Hewawasam, W Fan, DA Cook, KS Newberry…

Index: Hewawasam, Piyasena; Fan, Wenhong; Cook, Deborah A.; Newberry, Kimberly S.; Boissard, Christopher G.; Gribkoff, Valentin K.; Starrett, John; Lodge, Nicholas J. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4479 - 4482

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Citation Number: 33

Abstract

A novel series of 4-aryl-3-(mercapto) quinolin-2-one derivatives was prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. In vivo efficacy has been demonstrated with a selective maxi-K opening relaxant in a rat ...