One-pot concise syntheses of benzimidazo [2, 1-a] isoquinolines by a microwave-accelerated tandem process

N Okamoto, K Sakurai, M Ishikura, K Takeda…

Index: Okamoto, Noriko; Sakurai, Keisuke; Ishikura, Minoru; Takeda, Kei; Yanada, Reiko Tetrahedron Letters, 2009 , vol. 50, # 28 p. 4167 - 4169

Full Text: HTML

Citation Number: 39

Abstract

Direct, efficient syntheses of the benzimidazo [2, 1-a] isoquinoline ring system have been achieved with 2-bromoarylaldehydes, terminal alkynes, and 1, 2-phenylenediamines by a microwave-accelerated tandem process in which a Sonogashira coupling, 5-endo cyclization, oxidative aromatization, and 6-endo cyclization can be performed in a single synthetic operation.

Related Articles:

Poly (ethylene glycol)(PEG) as an efficient and recyclable reaction medium for the synthesis of dibenz [b, f]-1, 4-oxazepine

[Jorapur, Yogesh R.; Rajagopal, Gurusamy; Saikia, Prakash J.; Pal, Ravindra R. Tetrahedron Letters, 2008 , vol. 49, # 9 p. 1495 - 1497]

Microwave assisted synthesis of dibenzoxazepines

[Ghafarzadeh, Mohammad; Moghadam, Ebrahim Saeedian; Faraji, Fereshteh Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 4 p. 754 - 757]

11H-dibenzo [b, e] azepines. Part 1. Synthesis and ir spectra of dibenzo [b, f][1, 4] oxazepines

[Noskov; Kalinina; Noskova; Kruglyak; Strukov; Bezrukov; Kurochkin Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 8 p. 431 - 434]

Microwave??Assisted Synthesis of Substituted Dibenzo [b, f][1, 4] thiazepines, Dibenzo [b, f][1, 4] oxazepines, Benzothiazoles, and Benzimidazoles

[Lin, Yu-Chin; Li, Ni-Ching; Cherng, Yie-Jia Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 3 p. 808 - 814]

Microwave??Assisted Synthesis of Substituted Dibenzo [b, f][1, 4] thiazepines, Dibenzo [b, f][1, 4] oxazepines, Benzothiazoles, and Benzimidazoles

[Lin, Yu-Chin; Li, Ni-Ching; Cherng, Yie-Jia Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 3 p. 808 - 814]

More Articles...