Synthesis and Muscarinic Activity of a Series of Quinolines and Naphthalenes with a 1-Azabicyclo (3.3. 0) octane Moiety.

…, T Usui, M Oka, T SUzuki, T KATAOKA

Index: Suzuki, Tomoo; Usui, Toshinao; Oka, Mitsuru; Suzuki, Tsunemasa; Kataoka, Tadashi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1265 - 1273

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Citation Number: 16

Abstract

In order to discover a medicine effective against Alzheimer's disease, we synthesized a series of quinoline derivatives having a characteristic 1-azabicyclo [3.3. 0] octane amine ring, and performed pharmacological evaluation of them. Acetylcholine esterase inhibitory activities of these derivatives were unexpectedly weak. Tests for central nervous muscarinic cholinergic receptor binding affinity indicated that these compounds had higher affinities ...