Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds

JR Dimmock, SC Vashishtha, JP Stables

Index: Dimmock, Jonathan R.; Vashishtha, Sarvesh C.; Stables, James P. European Journal of Medicinal Chemistry, 2000 , vol. 35, # 2 p. 241 - 248

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Citation Number: 229

Abstract

Various acetylhydrazones, oxamoylhydrazones and semicarbazones were prepared as candidate anticonvulsants with a view to examining the viability of a putative binding site hypothesis. Atomic charge calculations were undertaken to determine the hydrogen bonding capacities of various molecules. The biological results obtained revealed that in general the acetylhydrazones and semicarbazones afforded good protection against convulsions ...