Synthesis and antimicrobial activity of aliphatic nitro compounds

NG Clark, B Croshaw, BE Leggetter…

Index: Clark,N.G. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 977 - 981

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Citation Number: 29

Abstract

Results The general formulas of the compounds studied are given in Chart I. The parent straight-chain 1-nitroalkanes (CnHzn+ lNOz, n= 1-6 and 8), at a concentration of loo0 pg/ml, did not inhibit the growth of any of the test organisms listed in Table I. The introduction of a bromine atom adjacent to the nitro group (1) enhanced the activity of these compounds somewhat but, with the exception of bromonitromethane (1, R= H), none of these ...