Facile N-formylation of amines using Lewis acids as novel catalysts

…, AR Kumar, G Sathaiah, VL Paul, M Sridhar, PS Rao

Index: Chandra Shekhar; Ravi Kumar; Sathaiah; Luke Paul; Sridhar, Madabhushi; Shanthan Rao Tetrahedron Letters, 2009 , vol. 50, # 50 p. 7099 - 7101

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Citation Number: 106

Abstract

In recent years, a number of methods have been reported on N-formylation of amines. Some of the useful formylation reagents are chloral, 7 formic acid-DCC, 8 formic acid-EDCI, 9 formic acid esters, 10 KF-alumina, 11 and other solid-supported reagents, 12 ammonium formate, 13 CDMT. 14 Many of the N-formylation methods have disadvantages such as expensive reagents, formation of side products, thermal instability, and difficult accessibility to ...