Chemistry Letters

CESIUM FLUORIDE PROMOTES SYNTHESIS OF RIBOOLIGONUCLEOTIDES VIA PHOSPHOTRIESTER APPROACH

H Takaku, T Nomoto, M Murata, T Hata

Index: Takaku, Hiroshi; Nomoto, Tadaaki; Murata, Mitsuho; Hata, Tsujiaki Chemistry Letters, 1980 , p. 1419 - 1422

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Citation Number: 8

Abstract

In the presence of cesium fluoride, the reactions of a fully protected 5′-O-dimethoxytrityl- 2′-O-tetrahydropyranyl-N-acylnucleoside 3′-(4-chlorophenyl, 5-chloro-8-quinolyl) phosphates with 5′-hydroxyl nucleosides proceeded rapidly under mild conditions to afford the corresponding ribodinucleoside monophosphates in good yields.

Convenient syntheses of oligoribonucleotides having 2'-5'and/or 3'-5'phosphodiester linkage.

[Ozaki, Hiroaki; Nakamoto, Akio; Shimidzu, Takeo Chemistry Letters, 1990 , # 6 p. 959 - 962]

A nucleotide dimer synthesis without protecting groups using montmorillonite as catalyst

[Joshi, Prakash C.; Aldersley, Michael F.; Zagorevskii, Dmitri V.; Ferris, James P. Nucleosides, Nucleotides and Nucleic Acids, 2012 , vol. 31, # 7 p. 536 - 566]