Synthesis and Antibacterial Activity of New 1. BETA.-Methylcarbapenems Having the Potential for Intramolecular Nonbonded S... O Interactions.

Y Nagao, H Iimori, KH Nam, S Sano…

Index: Nagao, Yoshimitsu; Iimori, Hitoshi; Nam, Ki Hong; Sano, Shigeki; Shiro, Motoo Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 12 p. 1660 - 1661

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Citation Number: 10

Abstract

Mercaptoacetyliminothiadiazoline derivatives (19, 20) useful for the pendant moiety of 1β- methylcarbapenem antibiotics were efficiently synthesized. Acetyl derivative (18) of 20 was submitted to X-ray analysis, and a significant nonbonded S… O close contact was recognized in the crystallographic structure. New 1β-methylcarbapenems (5, 6) were synthesized by exploiting 19 and 20, and exhibited considerable antibacterial activities in ...