Tetrahedron Letters

Direct cyclization of ortho-(1H-pyrrol-1-yl) aryl and heteroaryl carboxylic acids into fused pyrrolizinones

F Aiello, A Garofalo, F Grande

Index: Aiello, Francesca; Garofalo, Antonio; Grande, Fedora Tetrahedron Letters, 2010 , vol. 51, # 50 p. 6635 - 6636

Full Text: HTML

Citation Number: 11

Abstract

A series of fused heterocyclic compounds based on a pyrrolizinone structure have been prepared from ortho-(1H-pyrrol-1-yl) aryl and heteroaryl carboxylic acids by intramolecular Friedel–Crafts acylation promoted by bis (trichloromethyl) carbonate, in generally good yield without using Lewis acid catalysts.

Related Articles:

Palladium??Catalysed Synthesis of 9H??Pyrrolo [1, 2??a] indol??9??ones and the Isomeric Indeno [2, 1??b] pyrrol??8??ones

[Wang, Shuyang; Yang, Qinghua; Dong, Jingjing; Li, Changwei; Sun, Li; Song, Chuanjun; Chang, Junbiao European Journal of Organic Chemistry, 2013 , # 33 p. 7631 - 7634]

More Articles...