An iminodiacetic acid based lanthanide binding tag for paramagnetic exchange NMR spectroscopy

JD Swarbrick, P Ung, S Chhabra…

Index: Swarbrick, James D.; Ung, Phuc; Chhabra, Sandeep; Graham, Bim Angewandte Chemie - International Edition, 2011 , vol. 50, # 19 p. 4403 - 4406

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Citation Number: 29

Abstract

When bound to proteins, paramagnetic lanthanide ions induce a range of effects that are observable by NMR spectroscopy, including pseudo-contact shifts (PCSs), paramagnetic relaxation enhancements (PREs), and residual dipolar couplings (RDCs).[1] These effects provide valuable constraints that can expedite protein structure refinement,[2] the analysis of protein–protein [3] and protein–ligand interactions,[4] and, potentially, the study of protein ...

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