Fluconazole analogues containing 2H-1, 4-benzothiazin-3 (4H)-one or 2H-1, 4-benzoxazin-3 (4H)-one moieties, a novel class of anti-Candida agents

…, SR Maujan, SP Sawargave, MA Chandavarkar…

Index: Borate, Hanumant B.; Maujan, Suleman R.; Sawargave, Sangmeshwer P.; Chandavarkar, Mohan A.; Vaiude, Sharangi R.; Joshi, Vinay A.; Wakharkar, Radhika D.; Iyer, Ramki; Kelkar, Ramesh G.; Chavan, Subhash P.; Kunte, Sunita S. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 722 - 725

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Citation Number: 28

Abstract

As a part of our program to develop new antifungal agents, a series of fluconazole analogues was designed and synthesized wherein one of the triazole moieties in fluconazole was replaced with 2H-1, 4-benzothiazin-3 (4H)-one or 2H-1, 4-benzoxazin-3 (4H)-one moiety. The new chemical entities thus synthesized were screened against various fungi and it was observed that the compounds 4a and 4i are potent inhibitors of Candida ...