Synthesis, DNA binding and in vitro antiproliferative activity of purinoquinazoline, pyridopyrimidopurine and pyridopyrimidobenzimidazole derivatives as potential …

…, G Primofiore, S Salerno, G Viola, L Dalla Via…

Index: Da Settimo, Antonio; Da Settimo, Federico; Marini, Anna Maria; Primofiore, Giampaolo; Salerno, Silvia; Viola, Giampietro; Dalla Via, Lisa; Marciani Magno, Sebastiano European Journal of Medicinal Chemistry, 1998 , vol. 33, # 9 p. 685 - 696

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Citation Number: 48

Abstract

In the search for new antitumor agents, 8, 10-dimethylpurino [7, 8-a] quinazoline-5, 9, 11 (6H, 8H, 10H)-triones 1, 8, 10-dimethylpyrido [2′, 3′: 4, 5] pyrimido [1, 2-f] purine-5, 9, 11 (6H, 8H, 10H)-triones 2, and 5, 7-dihydro-5-oxopyrido [3′, 2′: 5, 6] pyrimido [1, 2-a] benzimidazoles 3, a series of new planar heteropolycyclic compounds, were synthesized. The approach to understanding their structure-activity relationship involved a physico- ...