A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase

…, Y Yang, AF Kluge, D Keith, J Finn, P Gallant…

Index: Yu, Xiang Y.; Hill, Jason M.; Yu, Guixue; Yang, Yifeng; Kluge, Arthur F.; Keith, Dennis; Finn, John; Gallant, Paul; Silverman, Jared; Lim, Audrey Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 541 - 544

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Citation Number: 35

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of quinoline inhibitors of C. albicans prolyl tRNA synthetase was identified. The most potent analogue, 2-(4-bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid, showed IC 50 =5 nM (Ca. ProRS) with high selectivity over the human enzyme. ... A series of quinoline ...