Novel pirfenidone analogs as antifibrotic agents: synthesis and antifibrotic evaluation of 2-Pyridones and fused pyridones

MMF Ismail, E Noaman

Index: Ismail, Magda M. F.; Noaman, Eman Medicinal Chemistry Research, 2005 , vol. 14, # 7 p. 382 - 403

Full Text: HTML

Citation Number: 9

Abstract

A new series of substituted 1-(2-ethylphenyl)-2-oxo-1, 2-dihydropyridine-3-carbonitriles have been synthesized. Moreover, substituted bicyclic derivatives eg thieno [3, 4-c] pyridone, pyrido [3, 4-c] pyridone, benzo [c] pyridone, and tricyclic derivatives, chromeno [3, 4-c] pyridones have been prepared and evaluated for their antifibrotic activity. Among the tested compounds, compounds 4d and 5a exhibited potent antifibrotic activity without ...