Puromycin analogs. Effect of aryl-substituted puromycin analogs on the ribosomal peptidyltransferase reaction

H Lee, KL Fong, R Vince

Index: Lee, Heejoo; Fong, Kei-Lai; Vince, Robert Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 304 - 308

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Citation Number: 11

Abstract

A series of ortho-and para-substituted bphenyhylpuromycin analagues were synthesized and evaluated as substrates for the peptidyltransferase reaction of Escherichia coli ribosomes. Kinetic results reveal that substitution of the p-methoxy group of the puromycin molecule alters the peptidyltransferase activity of the molecule with the following decreasing order of substrate efficiencies: p-NH2> p-NHCOCHS> p-NOz= p-NHCO (CH&2HS> p- ...