Furanyl-1, 3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor

SM Courtney, PA Hay, RT Buck, CS Colville…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 9 p. 2295 - 2299

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Citation Number: 23

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Although a relatively weak starting point for a medicinal chemistry programme, the paucity of reported heparanase inhibitors, coupled with its scope for structural changes, encouraged us to explore the SAR of this scaffold. ...