Nicotinic acid adenine dinucleotide phosphate analogues containing substituted nicotinic acid: effect of modification on Ca2+ release

P Jain, JT Slama, LRA Perez-Haddock…

Index: Jain, Pooja; Slama, James T.; Perez-Haddock, Leroy A.; Walseth, Timothy F. Journal of Medicinal Chemistry, 2010 , vol. 53, # 21 p. 7599 - 7612

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Citation Number: 14

Abstract

Analogues of nicotinic acid adenine dinucleotide phosphate (NAADP) with substitution at either the 4-or the 5-position position of the nicotinic acid moiety have been synthesized from NADP enzymatically using Aplysia californica ADP-ribosyl cyclase or mammalian NAD glycohydrolase. Substitution at the 4-position of the nicotinic acid resulted in the loss of agonist potency for release of Ca2+-ions from sea urchin egg homogenates and in ...