6-(4-Phenyl-benzyloxy-methyl) guvacine. Synthesis, GABA uptake inhibitor and muscarinic properties

P Bisel, JP Gies, G Schlewer, CG Wermuth

Index: Bisel, Philippe; Gies, Jean Pierre; Schlewer, Gilbert; Wermuth, Camille G. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 24 p. 3025 - 3028

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Citation Number: 8

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... 6-(4-Phenyl-benzyloxy-methyl) guvacine was synthesized. Surprisingly the compound was devoid of the γ-aminobutyric acid (GABA) uptake inhibitory activity of its parent compound guvacine, but instead showed affinities for the muscarinic M 1 and M 2 receptors.