Synthesis of new fluoroquinolones and evaluation of their in vitro activity on Toxoplasma gondii and Plasmodium spp

…, N Mahmoudi, M Santillana-Hayat, R Gozalbes…

Index: Anquetin; Rouquayrol; Mahmoudi; Santillana-Hayat; Gozalbes; Greiner; Farhati; Derouin; Guedj; Vierling Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 11 p. 2773 - 2776

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Citation Number: 39

Abstract

The synthesis of four new computer-designed fluoroquinolones which have been predicted by QSAR analysis to be active against the protozoa Toxoplasma gondii is described. These compounds are inhibitory in vitro for T. gondii. One of these compounds has a remarkably high activity comparable to that of trovafloxacin. It combines the basic cyclopropyl–quinoline structure of gatifloxacin or moxifloxacin with the C-7 6-amino-3-azabicyclo [3.1. 0] hexyl ...