Stereodivergent syntheses of the first bis (cyclobutane) β-dipeptides

…, AG Moglioni, V Branchadell, RM Ortuño

Index: Izquierdo, Sandra; Martin-Vila, Marta; Moglioni, Albertina G.; Branchadell, Vicenc; Ortuo, Rosa M. Tetrahedron Asymmetry, 2002 , vol. 13, # 22 p. 2403 - 2405

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Citation Number: 21

Abstract

The efficient synthesis of methyl 2-benzyloxycarbonylamino-(1S, 2R)-cyclobutane-1- carboxylate starting from 2-methoxycarbonyl-(1R, 2S)-cyclobutane-1-carboxylic acid is described. This β-amino acid derivative is antipodal with respect to the (1R, 2S)-compound that was previously synthesized in our laboratory from the same chiral hemi ester. In turn, these enantiomeric β-amino acids have been self-condensed and coupled with one ...