Tetrahedron letters

Trifluoromethylation of aromatic compounds with sodium trifluoromethanesulfinate under oxidative conditions.

BR Langlois, E Laurent, N Roidot

Index: Langlois, Bernard R.; Laurent, Eliane; Roidot, Nathalie Tetrahedron Letters, 1991 , vol. 32, # 51 p. 7525 - 7528

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Citation Number: 172

Abstract

Abstract: Electron-rich aromatic compounds arc trifluoromethylated with sodium trifluoromethanesulfinate and t-butyl hydroperoxide. Monotrifluoromethylation predominates in the presence of catalytic amounts of Cu (II) triflate whereas mono-and bis- trifluoromethylated aromatics are ohtained in almost equal quantities in the absence of Cu (II).