Stereoselective cyanation of chiral α-amino aldehydes by reaction with Nagata's reagent: a route to enantiopure β-amino-α-hydroxy acids

…, MA Martı́nez, R Pedrosa, A Pérez-Encabo

Index: Andres, Jose M.; Martinez, Maria A.; Pedrosa, Rafael; Perez-Encabo, Alfonso Tetrahedron Asymmetry, 2001 , vol. 12, # 2 p. 347 - 353

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Citation Number: 35

Abstract

Chiral α-dibenzylamino aldehydes react with diethylaluminum cyanide leading to anti-β- dibenzylamino-α-hydroxycyanides as the major diastereoisomers in good yields and diastereomeric excesses. Hydrolysis of the nitrile derivatives allows the synthesis of enantiopure β-amino-α-hydroxy acids.

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