Kinetic resolution of amino alcohol derivatives with a chiral nucleophilic catalyst: access to enantiopure cyclic cis-amino alcohols

T Kawabata, K Yamamoto, Y Momose…

Index: Kawabata; Yamamoto; Momose; Yoshida; Nagaoka; Fuji Chemical Communications, 2001 , # 24 p. 2700 - 2701

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Citation Number: 51

Abstract

Acylative kinetic resolution of racemic cyclic cis-amino alcohol derivatives with a chiral nucleophilic catalyst proceeds enantioselectively (s= 10–21) at ambient temperature to give enantiopure recovered materials, and the% conversion of the acylation can be readily controlled by the amount of acid anhydride.

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