Synthesis of 2??[4??(Imidazolin??2??Ylideneamino) Benzyl]??Indan??1??Ones as Novel Potent Prostacyclin Antagonists

CY Chern, YL Yek, YL Chen…

Index: Chern, Ching-Yuh; Yek, Yung-Lee; Chen, Yu-Lin; Kan, Wai-Ming Journal of the Chinese Chemical Society, 2008 , vol. 55, # 4 p. 846 - 853

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Abstract

Abstract Prostacyclin is involved in many pathological conditions, such as sensitization of inflammation induced pain and isovolumetic distention. Therefore, antagonism of prostacyclin action may be useful in the alleviation of these conditions. In this study, novel potent prostacyclin antagonists, 2-[4-(imidazolin-2-ylideneamino) benzyl]-indan-1-ones were synthesized from their respective substituted indanones in three steps. The ...