4-Amino-2-styrylquinazolines, a new class of antiprotozoal drugs

NY Moskalenko, LN Yakhontov, GP Zhikhareva…

Index: Moskalenko, N. Yu.; Yakhontov, L. N.; Zhikhareva, G. P.; Pershin, G. N.; Perets, V. V.; et al. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 4 p. 265 - 273 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 4 p. 437 - 446

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Abstract

Pursuing this novel direction of research, some ten years ago we developed general methods for the synthesis of previously unknown aza-analogs of styrylquinolines, namely 4- amino-2-styrylquinazolines (I)[15, 16]. These methods were based on the reaction of 2- methyl-4-chloroquinazolines (V), obtained from the anthranilic acids (II) or acetanilides (III) via the 2-methyl-4-quinazolones (IV) with amines, followed by condensation of the ...