Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives

…, X Zhai, QH Yuan, J Luo, SC Xie, P Gong

Index: Chen, Dong; Zhai, Xin; Yuan, Qiu Hui; Luo, Jian; Xie, Si Chang; Gong, Ping Chinese Chemical Letters, 2010 , vol. 21, # 11 p. 1326 - 1329

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Citation Number: 4

Abstract

A series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti- hepatitis B virus (HBV) activity and cytotoxicity in HepG2. 2.15 cells. Half of the tested compounds were found to be potent against HBsAg secretion with IC50 values less than 100μmol/L. Compounds 14c, 14d, and 14e showed significant inhibitory activity to the viral antigen HBeAg.