Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia

G Nowak, DF Grant, JH Moran

Index: Nowak, Grazyna; Grant, David F.; Moran, Jeffery H. Toxicology Letters, 2004 , vol. 147, # 2 p. 161 - 175

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Citation Number: 15

Abstract

Low concentrations of arachidonic acid monoepoxides protect against ischemia/reperfusion injury. This study examined whether low concentrations of the linoleic acid monoepoxide, cis- 12, 13-epoxy-9-octadecenoic acid (12, 13-EOA), protect renal cells against decreases in mitochondrial and transport functions induced by hypoxia/reoxygenation. Primary cultures of rabbit renal proximal tubular cells (RPTC) were pretreated with diluent or 1, 5, or 10μM 12, ...