Development and scale-up of the electrochemical dehalogenation for the synthesis of a key intermediate for NS5A inhibitors

…, C Bucher, TR Galvão, SR Waldvogel

Index: Kulisch, Joern; Nieger, Martin; Stecker, Florian; Fischer, Andreas; Waldvogel, Siegfried R. Angewandte Chemie - International Edition, 2011 , vol. 50, # 24 p. 5564 - 5567

Full Text: HTML

Citation Number: 10

Abstract

The electrochemical 2-fold dehalogenation of a spirocyclopropane-proline derivative at leaded bronze was scaled-up in a divided batch-type electrolysis cell in good yield and excellent selectivity. The upscaling via a flow electrolysis cell was also successful.