2 H NMR evidence for dynamic disorder in human skin induced by the penetration enhancer azone

FR Bezema, E Marttin, PEH Roemele, J Brussee…

Index: Bezema; Marttin; Roemele; Brussee; Bodde; De Groot Spectrochimica Acta - Part A Molecular Spectroscopy, 1996 , vol. 52, # 7 PART A p. 785 - 791

Full Text: HTML

Citation Number: 9

Abstract

Penetration enhancers mediate trans-dermal drug delivery. The penetration enhancer dodecyl-azacycloheptanone (Azone®) was characterized in situ with 2H NMR on human stratum corneum treated with either uniformly deuterated Azone® or penetration enhancer with only the entire chain deuterated, in both cases in propylene glycol. The 2H NMR spectrum at ambient temperature constitutes a single narrow line only 180 Hz wide. This ...