Bioorganic & medicinal chemistry

Synthesis and evaluation of α, α-disubstituted-3-mercaptopropanoic acids as inhibitors for carboxypeptidase A and implications with respect to enzyme inhibitor …

HS Lee, DH Kim

Index: Lee, Hyun Soo; Kim, Dong H. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4685 - 4691

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Citation Number: 13

Abstract

2-Ethyl-2-methyl-3-mercaptopropanoic acid (6) and 2-benzyl-2-methyl-3-mercaptopropanoic acid (7) were synthesized and evaluated as inhibitors for carboxypeptidase A (CPA), a prototypical zinc protease with the expectation that the binding affinities of these inhibitors