An enantioselective synthesis of (R)-4-piperidinylglycine
WC Shieh, S Xue, N Reel, R Wu, J Fitt, O Repič
Index: Shieh, Wen-Chung; Xue, Song; Reel, Noela; Wu, Raeann; Fitt, John; Repic, Oljan Tetrahedron Asymmetry, 2001 , vol. 12, # 17 p. 2421 - 2425
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Citation Number: 15
Abstract
An efficient process for the synthesis of (R)-Nt-Boc-4-piperidinylglycine 8a, an unnatural amino acid, via enantioselective rhodium-catalyzed hydrogenation of the Cbz-enamide 5a is described. Subsequent deprotection of 8a affords unprotected (R)-4-piperidinylglycine 9 in good yield.
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