Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids

…, K Benakli, S Beaubien, C Saint-Louis, R Déziel…

Index: Marsault, Eric; Benakli, Kamel; Beaubien, Sylvie; Saint-Louis, Carl; Deziel, Robert; Fraser, Graeme Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 15 p. 4187 - 4190

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Citation Number: 20

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Novel, potent small molecule motilin receptor antagonists are described. These peptidomimetic macrocycles are composed of a tripeptide cyclized backbone-to-backbone with a nonpeptidic tether and bear new unnatural amino acids containing basic side chains.