Application of Grignard reagents to the synthesis of tertiary methylamines via resin-bound oxyiminium ions
P Blaney, R Grigg, Z Rankovic, M Thoroughgood
Index: Blaney; Grigg; Rankovic; Thoroughgood Tetrahedron Letters, 2000 , vol. 41, # 34 p. 6639 - 6642
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Citation Number: 19
Abstract
The solid-phase synthesis of tertiary methylamines via the nucleophilic displacement of benzotriazole Mannich adducts with Grignard reagents using a hydroxylamine linker is described. The chemistry is exemplified by the synthesis of the MAO inhibitor α- methylpargyline. Also described is the synthesis of the analgesic Tramadol by an alternative one-pot solid-phase Mannich reaction.
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